Details of Microbe Species (MIC)

General Information of MIC (ID: MC0044)
  MIC Name
Actinomyces naeslundii
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Actinomycetales
Family: Actinomycetaceae
Genus: Actinomyces
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Opportunistic pathogen
  No. of Coding Genes
2602
  No. of Non-Coding Genes
54
  No. of Small Non-Coding Genes
54
  No. of Gene Transcripts
2755
  No. of Pseudogenes 99
  Description
Actinomyces naeslundii is a gram-positive, rod-shaped bacteria found in the mouth of humans. The species has been implicated in periodontal disease, as well as various tooth cavities.
  External Links Taxonomy ID 1655
GutMDisorder ID gm0018
Genome Assembly ID ASM193759v1
GOLD Database ID Go0004264
GIMICA ID MIC00033

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [2]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Effect of reduced nutritional supply on the metabolic activity and survival of cariogenic bacteria in vitro J Oral Microbiol. 2019 Apr 22;11(1):1605788. doi: 10.1080/20002297.2019.1605788. eCollection 2019.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.

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