Details of Microbe Species (MIC)

General Information of MIC (ID: MC0011)
  MIC Name
Akkermansia muciniphila
  Lineage Kingdom: Bacteria
Phylum: Verrucomicrobia
Class: Verrucomicrobiae
Order: Verrucomicrobiales
Family: Akkermansiaceae
Genus: Akkermansia
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Commensal
  No. of Coding Genes
2121
  No. of Non-Coding Genes
75
  No. of Small Non-Coding Genes
75
  No. of Gene Transcripts
2196
  No. of Base Pairs
2745273
  Description
Akkermansia muciniphila is a species of gram-negative, anaerobic bacteria from the genus Akkermansia.
  External Links Taxonomy ID 239935
GutMDisorder ID gm0030
Genome Assembly ID ASM283416v1
GOLD Database ID Go0004253
GIMICA ID MIC00056

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [4], [5]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [3], [2]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [4], [5]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 The Effects of Vegetarian and Vegan Diets on Gut Microbiota Front Nutr. 2019 Apr 17;6:47. doi: 10.3389/fnut.2019.00047. eCollection 2019.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
4 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
5 Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids mBio. 2014 Aug 12;5(4):e01438-14. doi: 10.1128/mBio.01438-14.

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