Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12445)
  Official Symbol
TMED1
  Official Full Name
Transmembrane P24 Trafficking Protein 1
  Synonym
IL1RL1LG;Transmembrane P24 Trafficking Protein 1;P24gamma1;Il1rl1l;P24g1;Transmembrane Emp24 Protein Transport Domain Containing 1;Transmembrane Emp24 Domain-Containing Protein 1;Putative T1/ST2 Receptor-Binding Protein;Transmembrane Emp24 Domain Containing 1;Tp24;Interleukin-1 Receptor-Like 1 Ligand;IL1RL1-Binding Protein;IL1RL1L
  Molecule Type
Protein coding
  Position On Chromosome
chr19(Start:10832067 - End:10836318)
  Strand
-
  Uniprot Entry
Q13445 
  ENSG ID
ENSG00000099203 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce TMED1 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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