Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12421)
  Official Symbol
STK11
  Official Full Name
Serine/Threonine Kinase 11
  Synonym
Serine/Threonine Kinase 11;LKB1;PJS;Serine/Threonine-Protein Kinase STK11;Polarization-Related Protein LKB1;Renal Carcinoma Antigen NY-REN-19;Serine/Threonine Kinase 11 (Peutz-Jeghers Syndrome);Serine/Threonine-Protein Kinase LKB1;Serine/Threonine-Protein Kinase 11;EC 2.7.11.1;HLKB1
  Molecule Type
Protein coding
  Position On Chromosome
chr19(Start:1177558 - End:1228431)
  Strand
+
  Uniprot Entry
Q15831 
  ENSG ID
ENSG00000118046 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4KA9: Burkitt lymphoma Burkitt Lymphoma [Burkitt lymphoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Resveratrol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Resveratrol could change tumor suppressor gene STK11 from hypermethylated to hypomethylated status in MDA-MB-231 breast cancer cells treated with resveratrol (100 M) at 48 h.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 2016 Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.

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