Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12379)
  Official Symbol
SCN7A
  Official Full Name
Sodium Voltage-Gated Channel Alpha Subunit 7
  Synonym
Sodium Voltage-Gated Channel Alpha Subunit 7;Nav2.1;Nav2.2;SCN6A;NaG;Sodium Channel Protein Cardiac And Skeletal Muscle Subunit Alpha;Putative Voltage-Gated Sodium Channel Subunit Alpha Nax;Sodium Channel Protein Type 7 Subunit Alpha;Sodium Channel, Voltage-Gated, Type VI, Alpha Polypeptide;Sodium Channel, Voltage Gated, Type VII Alpha Subunit;Sodium Channel, Voltage-Gated, Type VII, Alpha;Voltage-Dependent Sodium Channel Alpha Subunit
  Molecule Type
Protein coding
  Position On Chromosome
chr2(Start:166403573 - End:166611482)
  Strand
-
  Uniprot Entry
Q01118 
  ENSG ID
ENSG00000136546 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         QA46: Outcome of delivery Fetal intolerance of labor [Outcome of delivery]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Docosahexaenoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Docosahexaenoic acid could altere the DNA methylation of SCN7A CpG loci.(cg24042978)

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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