Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12061)
  Official Symbol
FGF13
  Official Full Name
Fibroblast Growth Factor 13
  Synonym
Fibroblast Growth Factor 13;FHF2;Fibroblast Growth Factor Homologous Factor 2;FGF2;LINC00889;DEE90;Long Intergenic Non-Protein Coding RNA 889
  Molecule Type
Protein coding
  Position On Chromosome
chrX(Start:138614727 - End:139222889)
  Strand
-
  Uniprot Entry
Q92913 
  ENSG ID
ENSG00000129682 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         ZERO(Not Found): Sex chromosome anomalies X-chromosome inactivation (XCI) [Sex chromosome anomalies]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Docosahexaenoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Docosahexaenoic acid could altere the DNA methylation of FGF13 CpG loci.(cg12705389)
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [1]
     Description
Valerate has been shown to hypermethylate FGF13 CpG site in breast cancer cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.

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