Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11960)
  Official Symbol
CARS2
  Official Full Name
Cysteinyl-TRNA Synthetase 2, Mitochondrial
  Synonym
Cysteinyl-TRNA Synthetase 2, Mitochondrial;Cysteinyl-TRNA Synthetase 2, Mitochondrial (Putative);Cysteine TRNA Ligase 2, Mitochondrial (Putative);Probable Cysteine--TRNA Ligase, Mitochondrial;EC 6.1.1.16;COXPD27;Cysteinyl-TRNA Synthetase;CysRS
  Molecule Type
Protein coding
  Position On Chromosome
chr13(Start:110641410 - End:110713603)
  Strand
-
  Uniprot Entry
Q9HA77 
  ENSG ID
ENSG00000134905 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         DD70: Crohn disease Crohn's disease [Crohn disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XH4KA9: Burkitt lymphoma Burkitt Lymphoma [Burkitt lymphoma]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce CARS2 gene hypermethylation in THP-1 cells.

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Host-gut microbiota metabolic interactions Science. 2012 Jun 8;336(6086):1262-7. doi: 10.1126/science.1223813. Epub 2012 Jun 6.

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