Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11891)
  Official Symbol
B3GAT1
  Official Full Name
Beta-1,3-Glucuronyltransferase 1
  Synonym
Beta-1,3-Glucuronyltransferase 1;Galactosylgalactosylxylosylprotein 3-Beta-Glucuronosyltransferase 1;Glucuronosyltransferase P;GlcAT-P;UDP-GlcUA:Glycoprotein Beta-1,3-Glucuronyltransferase;EC 2.4.1.135;GLCATP;CD57 Antigen;LEU7 Antigen
  Molecule Type
Protein coding
  Position On Chromosome
chr11(Start:134378504 - End:134412242)
  Strand
-
  Uniprot Entry
Q9P2W7 
  ENSG ID
ENSG00000109956 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypomethylateB3GAT1 CpG site in breast cancer cells.
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Arachidonic acid could induce B3GAT1 gene hypermethylation in THP-1 cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4 Dietary proline supplementation alters colonic luminal microbiota and bacterial metabolite composition between days 45 and 70 of pregnancy in Huanjiang mini-pigs J Anim Sci Biotechnol. 2018 Jan 30;9:18. doi: 10.1186/s40104-018-0233-5. eCollection 2018.

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