Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11722)
  Official Symbol
TSC2
  Official Full Name
TSC complex subunit 2
  Synonym
LAM;PPP1R160;TSC4;tuberin
  Molecule Type
Protein coding
  Position On Chromosome
chr16(Start:2047967 - End:2089491)
  Strand
+
  Uniprot Entry
P49815 
  ENSG ID
ENSG00000103197 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Resveratrol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Resveratrol could change tumor suppressor gene TSC2 from hypermethylated to hypomethylated status in MDA-MB-231 breast cancer cells treated with resveratrol (100 M) at 48 h.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 2016 Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.

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