Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11709)
  Official Symbol
TOP1MT
  Official Full Name
DNA topoisomerase I mitochondrial
  Molecule Type
Protein coding
  Position On Chromosome
chr8(Start:143304384 - End:143359979)
  Strand
-
  Uniprot Entry
Q969P6 
  ENSG ID
ENSG00000184428 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce TOP1MT gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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