Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM05255)
  Official Symbol
PRPF4
  Official Full Name
pre-mRNA processing factor 4
  Synonym
HPRP4;HPRP4P;PRP4;Prp4p;SNRNP60
  Molecule Type
Protein coding
  Position On Chromosome
chr9(Start:113275343 - End:113292905)
  Strand
+
  Uniprot Entry
O43172 
  ENSG ID
ENSG00000136875 
  Dnmivd Disease
LUSC 
    Disease Relevance (Click to Show/Hide)
         8A40: Multiple sclerosis Multiple sclerosis [Multiple sclerosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH3DV3: Adenoma Adenoma [Adenoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce PRPF4 gene hypermethylation in THP-1 cells.

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host PRPF4 (geneBody) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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