Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12442)
  Official Symbol
TLX1
  Official Full Name
T Cell Leukemia Homeobox 1
  Synonym
HOX11;T Cell Leukemia Homeobox 1;TCL3;Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint, Homologous To Drosophila Notch);T-Cell Leukemia Homeobox Protein 1;Homeo Box 11 (T-Cell Lymphoma 3-Associated Breakpoint);T-Cell Leukemia, Homeobox 1;T-Cell Leukemia Homeobox 1;Proto-Oncogene TCL-3;T-Cell Leukemia/Lymphoma Protein 3
  Molecule Type
Protein coding
  Position On Chromosome
chr10(Start:101130773 - End:101137789)
  Strand
+
  Uniprot Entry
P31314 
  ENSG ID
ENSG00000107807 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce TLX1 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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