Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12439)
  Official Symbol
THRSP
  Official Full Name
Thyroid Hormone Responsive
  Synonym
Thyroid Hormone Responsive;SPOT14;S14;Lpgp;THRP;Thyroid Hormone-Inducible Hepatic Protein;Thyroid Hormone Responsive (SPOT14 Homolog, Rat);Thyroid Hormone Responsive SPOT14 (Rat) Homolog;SPOT14 Homolog (Rat);SPOT14 Homolog
  Molecule Type
Protein coding
  Position On Chromosome
chr11(Start:78063861 - End:78068351)
  Strand
+
  Uniprot Entry
Q92748 
  ENSG ID
ENSG00000151365 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         QA46: Outcome of delivery Fetal intolerance of labor [Outcome of delivery]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Docosahexaenoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Docosahexaenoic acid could altere the DNA methylation of THRSP CpG loci.(cg09721595)

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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