Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12437)
  Official Symbol
TFAP2D
  Official Full Name
Transcription Factor AP-2 Delta
  Synonym
AP-2delta;Transcription Factor AP-2 Delta;TFAP2BL1;Transcription Factor AP-2 Beta (Activating Enhancer-Binding Protein 2 Beta)-Like 1;Transcription Factor AP-2 Delta (Activating Enhancer Binding Protein 2 Delta);AP2-Delta;Activating Enhancer Binding Protein 2 Beta-Like 1;AP-2 Like
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:50713526 - End:50773033)
  Strand
+
  Uniprot Entry
Q7Z6R9 
  ENSG ID
ENSG00000008197 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce TFAP2D gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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