Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12436)
Official Symbol		TFAM
Official Full Name		Transcription Factor A, Mitochondrial
Synonym		Transcription Factor A, Mitochondrial;TCF6L2;Mitochondrial Transcription Factor 1;TCF6;Transcription Factor 6;Transcription Factor 6-Like 2 (Mitochondrial Transcription Factor);Mitochondrial Transcription Factor A;Transcription Factor 6-Like 1;Transcription Factor 6-Like 3;TCF6L3;MTTF1;MTTFA;MtTFA;MtTF1;TCF-6
Molecule Type		Protein coding
Position On Chromosome		chr10(Start:58385345 - End:58399220)
Strand		+
Uniprot Entry		Q00059
ENSG ID		ENSG00000108064
Disease Relevance (Click to Show/Hide)
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Hydrogen sulfide (H2S)
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Hydrogen sulfide (H2S) has been shown to inhibit mitochondrial transcription factor A (TFAM) promoter methylation.

References
1	Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM. Antioxid Redox Signal. 2015 Sep 1;23(7):630-42. doi: 10.1089/ars.2014.6186. Epub 2015 May 14.
2	Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice Endocrinology. 2017 Oct 1;158(10):3416-3425. doi: 10.1210/en.2017-00391.

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