Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12435)
  Official Symbol
TET1
  Official Full Name
Tet Methylcytosine Dioxygenase 1
  Synonym
Tet Methylcytosine Dioxygenase 1;Leukemia-Associated Protein With A CXXC Domain;LCX;BA119F7.1;KIAA1676;Ten-Eleven Translocation 1 Gene Protein;CXXC6;Methylcytosine Dioxygenase TET1;TET1 Splice Variant VP_DE456;Ten-Eleven Translocation 1;EC 1.14.11.N2;CXXC Zinc Finger 6;CXXC-Type Zinc Finger Protein 6
  Molecule Type
Protein coding
  Position On Chromosome
chr10(Start:68560337 - End:68700794)
  Strand
+
  Uniprot Entry
Q8NFU7 
  ENSG ID
ENSG00000138336 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         DD70: Crohn disease Crohn's disease [Crohn disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce TET1 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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