Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12412)
  Official Symbol
SPANXN3
  Official Full Name
SPANX Family Member N3
  Synonym
SPANX Family Member N3;SPANX-N3;CT11.8;Sperm Protein Associated With The Nucleus On The X Chromosome N3;Cancer/Testis Antigen Family 11, Member 8;Nuclear-Associated Protein SPAN-Xn3;SPANX Family, Member N3
  Molecule Type
Protein coding
  Position On Chromosome
chrX(Start:143508735 - End:143517475)
  Strand
-
  Uniprot Entry
Q5MJ09 
  ENSG ID
ENSG00000189252 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         ZERO(Not Found): Sex chromosome anomalies X-chromosome inactivation (XCI) [Sex chromosome anomalies]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce SPANXN3 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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