Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12398)
  Official Symbol
SLC39A6
  Official Full Name
Solute Carrier Family 39 Member 6
  Synonym
Solute Carrier Family 39 Member 6;LIV-1;Solute Carrier Family 39 (Metal Ion Transporter), Member 6;Solute Carrier Family 39 (Zinc Transporter), Member 6;Estrogen-Regulated Protein LIV-1;ZIP-6;LIV1;ZIP6;LIV-1 Protein, Estrogen Regulated
  Molecule Type
Protein coding
  Position On Chromosome
chr18(Start:36108531 - End:36129385)
  Strand
-
  Uniprot Entry
Q13433 
  ENSG ID
ENSG00000141424 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: S-Adenosyl Methionine (SAM)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
S-Adenosylmethionine was proved to be increase SLC39A6 methylation in HT-29 cells.(P value = 0.043)

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3. Hum Mol Genet. 2013 Jul 1;22(13):2662-75. doi: 10.1093/hmg/ddt115. Epub 2013 Mar 7.

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