Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12393)
Official Symbol		SLC24A1
Official Full Name		Solute Carrier Family 24 Member 1
Synonym		Solute Carrier Family 24 Member 1;NCKX1;KIAA0702;HsT17412;CSNB1D;NCKX;Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 1;Sodium/Potassium/Calcium Exchanger 1;Na(+)/K(+)/Ca(2+)-Exchange Protein 1;Retinal Rod Na+/Ca+/K+ Exchanger;Retinal Rod Na-Ca+K Exchanger
Molecule Type		Protein coding
Position On Chromosome		chr15(Start:65611313 - End:65661002)
Strand		+
Uniprot Entry		O60721
ENSG ID		ENSG00000074621
Disease Relevance (Click to Show/Hide)
6B01: Panic disorder		Panic Disorder [Panic disorder]
Detailed Information		Disease Link click to show the detail information of this Disease
8A01: Choreiform disorders		Huntington's disease (HD) [Choreiform disorders]
Detailed Information		Disease Link click to show the detail information of this Disease
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease
CB03: Idiopathic interstitial pneumonitis		Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Arachidonic acid
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Arachidonic acid could induce SLC24A1 gene hypermethylation in THP-1 cells.

References
1	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2	Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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