Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12369)
  Official Symbol
RPL5
  Official Full Name
Ribosomal Protein L5
  Synonym
PPP1R135;UL18;Ribosomal Protein L5;L5;Protein Phosphatase 1, Regulatory Subunit 135;Large Ribosomal Subunit Protein UL18;60S Ribosomal Protein L5;MSTP030
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:92831986 - End:92841924)
  Strand
+
  Uniprot Entry
P46777 
  ENSG ID
ENSG00000122406 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         QA46: Outcome of delivery Fetal intolerance of labor [Outcome of delivery]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Resveratrol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Resveratrol could change tumor suppressor gene RPL5 from hypermethylated to hypomethylated status in MDA-MB-231 breast cancer cells treated with resveratrol (100 M) at 48 h.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 2016 Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.

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