Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12359)
  Official Symbol
RHOU
  Official Full Name
Ras Homolog Family Member U
  Synonym
CDC42L1;Ras Homolog Family Member U;WRCH1;Ryu GTPase;WRCH-1;HG28K;ARHU;Rho-Related GTP-Binding Protein RhoU;Ras Homolog Gene Family, Member U ;GTP-Binding Protein SB128;CDC42-Like GTPase 1;2310026M05Rik;DJ646B12.2;FJ646B12.2;FLJ10616;G28K;Wnt-1 Responsive Cdc42 Homolog
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:228644647 - End:228746669)
  Strand
+
  Uniprot Entry
Q7L0Q8 
  ENSG ID
ENSG00000116574 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         QA46: Outcome of delivery Fetal intolerance of labor [Outcome of delivery]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce RHOU gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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