Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12340)
  Official Symbol
PSMB9
  Official Full Name
Proteasome 20S Subunit Beta 9
  Synonym
Proteasome 20S Subunit Beta 9;RING12;PSMB6i;Beta1i;LMP2;Multicatalytic Endopeptidase Complex Chain 7;Really Interesting New Gene 12 Protein;Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Peptidase 2);Proteasome (Prosome, Macropain) Subunit, Beta Type, 9 (Large Multifunctional Protease 2);Proteasome (Prosome, Macropain) Subunit, Beta Type, 9;Proteasome Catalytic Subunit 1i
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:32844136 - End:32859851)
  Strand
+
  Uniprot Entry
P28065 
  ENSG ID
ENSG00000240065 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         6B01: Panic disorder Panic Disorder [Panic disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce PSMB9 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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