Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12332)
  Official Symbol
PRDM11
  Official Full Name
PR/SET Domain 11
  Synonym
PR/SET Domain 11;PR-Domain Containing Protein 11;PFM8;PR Domain-Containing Protein 11;PR Domain Containing 11;PR Domain 11;EC 2.1.1
  Molecule Type
Protein coding
  Position On Chromosome
chr11(Start:45094159 - End:45235114)
  Strand
+
  Uniprot Entry
Q9NQV5 
  ENSG ID
ENSG00000019485 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
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         6B01: Panic disorder Panic Disorder [Panic disorder]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2B: Syndromes with premature ageing appearance as a major feature Werner Syndrome [Syndromes with premature ageing appearance as a major feature]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XH4KA9: Burkitt lymphoma Burkitt Lymphoma [Burkitt lymphoma]
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         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce PRDM11 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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