Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12325)
  Official Symbol
PPA2
  Official Full Name
Inorganic Pyrophosphatase 2
  Synonym
Inorganic Pyrophosphatase 2;Inorganic Pyrophosphatase 2, Mitochondrial;Pyrophosphate Phospho-Hydrolase 2;Pyrophosphatase (Inorganic) 2;Pyrophosphatase SID6-306;EC 3.6.1.1;PPase 2;SID6-306;SCFAI;SCFI;FLJ20459
  Molecule Type
Protein coding
  Position On Chromosome
chr4(Start:105369077 - End:105474070)
  Strand
-
  Uniprot Entry
Q9H2U2 
  ENSG ID
ENSG00000138777 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce PPA2 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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