Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12321)
Official Symbol		PNMA1
Official Full Name		PNMA Family Member 1
Synonym		PNMA Family Member 1;Neuron- And Testis-Specific Protein 1;MA1;Paraneoplastic Ma Antigen 1;Paraneoplastic Antigen Ma1;37 KDa Neuronal Protein;Paraneoplastic Neuronal Antigen MA1
Molecule Type		Protein coding
Position On Chromosome		chr14(Start:73711783 - End:73714384)
Strand		-
Uniprot Entry		Q8ND90
ENSG ID		ENSG00000176903
Disease Relevance (Click to Show/Hide)
8A01: Choreiform disorders		Huntington's disease (HD) [Choreiform disorders]
Detailed Information		Disease Link click to show the detail information of this Disease
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease
CB03: Idiopathic interstitial pneumonitis		Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
Detailed Information		Disease Link click to show the detail information of this Disease
LD2C: Overgrowth syndromes		Sotos syndrome(SS) [Overgrowth syndromes]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Arachidonic acid
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Arachidonic acid could induce PNMA1 gene hypermethylation in THP-1 cells.

References
1	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2	Intermediaries of branched chain amino acid metabolism induce fetal hemoglobin, and repress SOX6 and BCL11A, in definitive erythroid cells. Blood Cells Mol Dis. 2015 Aug;55(2):161-7. doi: 10.1016/j.bcmd.2015.05.006. Epub 2015 May 27.

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