Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12301)
  Official Symbol
PAK5
  Official Full Name
P21 (RAC1) Activated Kinase 5
  Synonym
P21 (RAC1) Activated Kinase 5;KIAA1264;P21 Protein (Cdc42/Rac)-Activated Kinase 7;Serine/Threonine-Protein Kinase PAK 5;P21(CDKN1A)-Activated Kinase 7;P21 (RAC1) Activated Kinase 7;P21-Activated Kinase 5;PAK-7;Serine/Threonine-Protein Kinase PAK 7;Serine/Threonine-Protein Kinase PAK7
  Molecule Type
Protein coding
  Position On Chromosome
chr20(Start:9537370 - End:9839076)
  Strand
-
  Uniprot Entry
Q9P286 
  ENSG ID
ENSG00000101349 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: S-Adenosyl Methionine (SAM)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
S-Adenosylmethionine was proved to be decrease PAK7 methylation in HT-29 cells.(P value = 0.047)

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3. Hum Mol Genet. 2013 Jul 1;22(13):2662-75. doi: 10.1093/hmg/ddt115. Epub 2013 Mar 7.

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