Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12272)
  Official Symbol
NTRK1
  Official Full Name
Neurotrophic Receptor Tyrosine Kinase 1
  Synonym
Neurotrophic Receptor Tyrosine Kinase 1;TRK;MTC;TRKA;High Affinity Nerve Growth Factor Receptor;Neurotrophic Tyrosine Kinase, Receptor, Type 1;TRK1-Transforming Tyrosine Kinase Protein;Tropomyosin-Related Kinase A;Tyrosine Kinase Receptor A;Trk-A;Neurotrophic Tyrosine Kinase Receptor Type 1
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:156815640 - End:156881850)
  Strand
+
  Uniprot Entry
P04629 
  ENSG ID
ENSG00000198400 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Resveratrol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Resveratrol could change tumor suppressor gene NTRK1 from hypomethylated to hypermethylated status in MDA-MB-231 breast cancer cells treated with resveratrol (100 M) at 48 h.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 2016 Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.

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