Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12260)
  Official Symbol
NLRP11
  Official Full Name
NLR Family Pyrin Domain Containing 11
  Synonym
NLR Family Pyrin Domain Containing 11;PYPAF6;NOD17;CLR19.6;PAN10;NALP11;Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing;Nucleotide-Binding Oligomerization Domain Protein 17;PAAD-And NACHT Domain-Containing Protein 10;PYRIN-Containing APAF1-Like Protein 6;PAAD- And NACHT-Containing Protein 10B;PYPAF7
  Molecule Type
Protein coding
  Position On Chromosome
chr19(Start:55785397 - End:55836800)
  Strand
-
  Uniprot Entry
P59045 
  ENSG ID
ENSG00000179873 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce NLRP11 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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