Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12204)
  Official Symbol
MCAT
  Official Full Name
Malonyl-CoA-Acyl Carrier Protein Transacylase
  Synonym
Malonyl-CoA-Acyl Carrier Protein Transacylase;FASN2C;MCT;MT;NET62;FabD;MCT1;[Acyl-Carrier-Protein] Malonyltransferase;Mitochondrial Malonyltransferase;Mitochondrial Malonyl CoA:ACP Acyltransferase;EC 2.3.1.39 4
  Molecule Type
Protein coding
  Position On Chromosome
chr22(Start:43132206 - End:43143398)
  Strand
-
  Uniprot Entry
Q8IVS2 
  ENSG ID
ENSG00000100294 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce MCAT gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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