General Information of EM (ID: EM12154)
  Official Symbol
KCNK3
  Official Full Name
Potassium Two Pore Domain Channel Subfamily K Member 3
  Synonym
Potassium Two Pore Domain Channel Subfamily K Member 3;TASK1;TASK;K2p3.1;TASK-1;Potassium Channel, Two Pore Domain Subfamily K, Member 3;Acid-Sensitive Potassium Channel Protein TASK-1;TWIK-Related Acid-Sensitive K(+) Channel 1L;Potassium Channel, Subfamily K, Member 3;TWIK-Related Acid-Sensitive K+ Channel
  Molecule Type
Protein coding
  Position On Chromosome
chr2(Start:26692722 - End:26733420)
  Strand
+
  Uniprot Entry
O14649 
  ENSG ID
ENSG00000171303 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         9B75: Macular disorders Age-related macular degeneration (AMD) [Macular disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce KCNK3 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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