Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12105)
  Official Symbol
HAT1
  Official Full Name
Histone Acetyltransferase 1
  Synonym
Histone Acetyltransferase 1;Histone Acetyltransferase Type B Catalytic Subunit;KAT1;EC 2.3.1.48
  Molecule Type
Protein coding
  Position On Chromosome
chr2(Start:171922425 - End:171983686)
  Strand
+
  Uniprot Entry
O14929 
  ENSG ID
ENSG00000128708 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Spermine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Spermine could increase the expression levels of HAT1 in HT1080 cells.

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. Int J Biol Macromol. 2014 Feb;63:56-63. doi: 10.1016/j.ijbiomac.2013.10.041. Epub 2013 Nov 1.

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