Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12088)
  Official Symbol
GNAT1
  Official Full Name
G Protein Subunit Alpha Transducin 1
  Synonym
G Protein Subunit Alpha Transducin 1;CSNBAD3;Guanine Nucleotide Binding Protein (G Protein), Alpha Transducing Activity Polypeptide 1;Guanine Nucleotide-Binding Protein G(T) Subunit Alpha-1;Transducin Alpha-1 Chain;GNATR;CSNB1G;GBT1;HG1F
  Molecule Type
Protein coding
  Position On Chromosome
chr3(Start:50191610 - End:50197696)
  Strand
+
  Uniprot Entry
P11488 
  ENSG ID
ENSG00000114349 
    Disease Relevance (Click to Show/Hide)
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Resveratrol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Resveratrol could change tumor suppressor gene GNAT1 from hypermethylated to hypomethylated status in MDA-MB-231 breast cancer cells treated with resveratrol (100 M) at 48 h.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 2016 Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.