Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12071)
Official Symbol		NR1H4
Official Full Name		Nuclear Receptor Subfamily 1 Group H Member 4
Synonym		Nuclear Receptor Subfamily 1 Group H Member 4;HRR1;FXR;HRR-1Retinoid X Receptor-Interacting Protein 14;Farnesoid X Receptor;PFIC5
Molecule Type		Protein coding
Position On Chromosome		chr12(Start:100473708 - End:100564414)
Strand		+
Uniprot Entry		Q96RI1
ENSG ID		ENSG00000012504

Metabolite(s) with this epigenetic modification
Metabolite Name: Deoxycholic acid
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Deoxycholic acid was significantly and negatively correlated with the methylation level at the proximal FXR/NR1H4-358 CpG site.

References
1	Promoter DNA methylation of farnesoid X receptor and pregnane X receptor modulates the intrahepatic cholestasis of pregnancy phenotype. PLoS One. 2014 Jan 31;9(1):e87697. doi: 10.1371/journal.pone.0087697. eCollection 2014.
2	A prospective cohort analysis of gut microbial co-metabolism in Alaska Native and rural African people at high and low risk of colorectal cancer Am J Clin Nutr. 2020 Feb 1;111(2):406-419. doi: 10.1093/ajcn/nqz301.

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