Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12065)
  Official Symbol
FLCN
  Official Full Name
Folliculin
  Synonym
Folliculin;DENND8B;BHD;BHD Skin Lesion Fibrofolliculoma Protein;Birt-Hogg-Dube Syndrome Protein;MGC17998;MGC23445;FLCL
  Molecule Type
Protein coding
  Position On Chromosome
chr17(Start:17206946 - End:17237188)
  Strand
-
  Uniprot Entry
Q8NFG4 
  ENSG ID
ENSG00000154803 
    Disease Relevance (Click to Show/Hide)
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2B: Syndromes with premature ageing appearance as a major feature Werner Syndrome [Syndromes with premature ageing appearance as a major feature]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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         ZERO(Not Found): Glomerular diseases IgA nephropathy [Glomerular diseases]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Resveratrol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Resveratrol could change tumor suppressor gene FLCN from hypermethylated to hypomethylated status in MDA-MB-231 breast cancer cells treated with resveratrol (100 M) at 48 h.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [1]
     Description
Valerate has been shown to hypermethylate FLCN CpG site in breast cancer cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 2016 Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.
3 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.

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