Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12037)
  Official Symbol
EIF3A
  Official Full Name
Eukaryotic Translation Initiation Factor 3 Subunit A
  Synonym
EIF3-Theta;Eukaryotic Translation Initiation Factor 3 Subunit A;EIF3-P170;KIAA0139;EIF3S10;TIF32;Eukaryotic Translation Initiation Factor 3, Subunit 10 Theta, 150/170kDa;Eukaryotic Translation Initiation Factor 3 Subunit 10;Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 170kD);Eukaryotic Translation Initiation Factor 3, Subunit 10, 170kD;Eukaryotic Translation Initiation Factor 3, Subunit A;Cytoplasmic Protein P167;Centrosomin Homolog;EIF3, P180 Subunit
  Molecule Type
Protein coding
  Position On Chromosome
chr10(Start:119033670 - End:119080823)
  Strand
-
  Uniprot Entry
Q14152 
  ENSG ID
ENSG00000107581 
    Disease Relevance (Click to Show/Hide)
         2A00: Primary neoplasms of brain Glioma []
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         2B6B: Malignant neoplasms of nasopharynx Nasopharyngeal carcinoma (NPC) []
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         2C25: Malignant neoplasms of bronchus or lung Non small cell lung cancer (NSCLC) []
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         2C60: Carcinoma of breast Breast cancer []
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) []
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         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease []
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         QA46: Outcome of delivery Fetal intolerance of labor [Outcome of delivery]
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         SD86: Dementia disorder Dementia []
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XH1XF3: Osteosarcoma Osteosarcoma []
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia []
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         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors []
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Resveratrol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Resveratrol could change tumor suppressor gene EIF3A from hypomethylated to hypermethylated status in MDA-MB-231 breast cancer cells treated with resveratrol (100 M) at 48 h.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 2016 Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.

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