Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12025)
  Official Symbol
DHX16
  Official Full Name
DEAH-Box Helicase 16
  Synonym
DEAH-Box Helicase 16;DBP2;PRPF2;Prp2;DDX16;Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX16;DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 16;DEAH (Asp-Glu-Ala-His) Box Polypeptide 16;DEAD/H Box 16;RNA Helicase;EC 3.6.4.13;KIAA0577;EC 3.6.1;PRO2014;NMOAS
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:30653119 - End:30673006)
  Strand
-
  Uniprot Entry
O60231 
  ENSG ID
ENSG00000204560 
    Disease Relevance (Click to Show/Hide)
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         DD70: Crohn disease Crohn's disease [Crohn disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce DHX16 gene hypermethylation in THP-1 cells.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [1]
     Description
Valerate has been shown to hypermethylate DHX16 CpG site in breast cancer cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.
3 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.

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