Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12021)
Official Symbol		DEFB108B
Official Full Name		Defensin Beta 108B
Synonym		Defensin Beta 108B;Defensin, Beta 108B;Beta-Defensin 108B;Beta-Defensin 8;DEFB-8;DEFB108;HBD-8;BD-8
Molecule Type		Protein coding
Position On Chromosome		chr11(Start:71833200 - End:71837710)
Strand		+
Uniprot Entry		Q8NET1
ENSG ID		ENSG00000184276
Disease Relevance (Click to Show/Hide)
2C30: Melanoma of skin		Cutaneous Melanoma [Melanoma of skin]
Detailed Information		Disease Link click to show the detail information of this Disease
8A01: Choreiform disorders		Huntington's disease (HD) [Choreiform disorders]
Detailed Information		Disease Link click to show the detail information of this Disease
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease
CB03: Idiopathic interstitial pneumonitis		Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
Detailed Information		Disease Link click to show the detail information of this Disease
LD2C: Overgrowth syndromes		Sotos syndrome(SS) [Overgrowth syndromes]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Arachidonic acid
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Arachidonic acid could induce DEFB108B gene hypermethylation in THP-1 cells.

References
1	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2	Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.

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