Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12019)
  Official Symbol
DDX21
  Official Full Name
DExD-Box Helicase 21
  Synonym
Nucleolar RNA Helicase 2;RH-II/GU;DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 21;Nucleolar RNA Helicase Gu;Nucleolar RNA Helicase II;DEAD-Box Helicase 21;DEAD Box Protein 21;DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 21;EC 3.6.4.13;RH-II/GuA
  Molecule Type
Protein coding
  Position On Chromosome
chr10(Start:68956131 - End:68985068)
  Strand
+
  Uniprot Entry
Q9NR30 
  ENSG ID
ENSG00000165732 
    Disease Relevance (Click to Show/Hide)
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce DDX21 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.

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