Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12014)
  Official Symbol
DAZL
  Official Full Name
Deleted In Azoospermia Like
  Synonym
Deleted In Azoospermia Like;SPGYLA;DAZL1;DAZH;Deleted In Azoospermia-Like;DAZLA;Deleted In Azoospermia-Like 1;Testis Secretory Sperm-Binding Protein Li 204a;Spermatogenesis Gene On The Y-Like Autosomal;Germline Specific RNA Binding Protein
  Molecule Type
Protein coding
  Position On Chromosome
chr3(Start:16586792 - End:16670306)
  Strand
-
  Uniprot Entry
Q92904 
  ENSG ID
ENSG00000092345 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce DAZL gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.

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