Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12012)
  Official Symbol
CYP4F22
  Official Full Name
Cytochrome P450 Family 4 Subfamily F Member 22
  Synonym
Cytochrome P450 Family 4 Subfamily F Member 22;Cytochrome P450, Family 4, Subfamily F, Polypeptide 22;Ultra-Long-Chain Fatty Acid Omega-Hydroxylase;Cytochrome P450 4F22;FLJ39501;INLNE;LI3;EC 1.14.14.177;Cytochrome P450, Family 2, Subfamily E, Polypeptide 2 Homolog
  Molecule Type
Protein coding
  Position On Chromosome
chr19(Start:15508487 - End:15552317)
  Strand
+
  Uniprot Entry
Q6NT55 
  ENSG ID
ENSG00000171954 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: S-Adenosyl Methionine (SAM)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
S-Adenosylmethionine was proved to be decrease CYP4F22 methylation in HT-29 cells.(P value = 0.033)

References
1 S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression. Cells. 2020 Aug 9;9(8):1864. doi: 10.3390/cells9081864.
2 Progress in the microbial production of S-adenosyl-L-methionine World J Microbiol Biotechnol. 2016 Sep;32(9):153. doi: 10.1007/s11274-016-2102-8. Epub 2016 Jul 27.

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