Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12009)
  Official Symbol
CTSA
  Official Full Name
Cathepsin A
  Synonym
Cathepsin A;Lysosomal Protective Protein;Carboxypeptidase C;Carboxypeptidase Y-Like Kininase;Protective Protein Cathepsin A;PPGB;Carboxypeptidase-L;Urinary Kininase;Beta-Galactosidase Protective Protein;Carboxypeptidase L;Beta-Galactosidase 2;EC 3.4.16;GLB2
  Molecule Type
Protein coding
  Position On Chromosome
chr20(Start:45,890,14 - End:45898949)
  Strand
+
  Uniprot Entry
P10619 
  ENSG ID
ENSG00000064601 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce CTSA gene hypermethylation in THP-1 cells.

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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