Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11980)
  Official Symbol
CHD5
  Official Full Name
Chromodomain Helicase DNA Binding Protein 5
  Synonym
Chromodomain-Helicase-DNA-Binding Protein 5;Chromodomain Helicase DNA Binding Protein 5;ATP-Dependent Helicase CHD5;CHD-5;KIAA0444;EC 3.6.1;EC 3.6.4.12
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:6101787 - End:6180321)
  Strand
+
  Uniprot Entry
Q8TDI0 
  ENSG ID
ENSG00000116254 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4KA9: Burkitt lymphoma Burkitt Lymphoma [Burkitt lymphoma]
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         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce CHD5 gene hypermethylation in THP-1 cells.

References
1 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
2 Stages of pregnancy and weaning influence the gut microbiota diversity and function in sows J Appl Microbiol. 2019 Sep;127(3):867-879. doi: 10.1111/jam.14344. Epub 2019 Jul 1.

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