Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11950)
  Official Symbol
COA1
  Official Full Name
Cytochrome C Oxidase Assembly Factor 1
  Synonym
Cytochrome C Oxidase Assembly Factor 1;MITRAC15;Cytochrome C Oxidase Assembly Factor 1 Homolog;C7orf44;Mitochondrial Translation Regulation Assembly Intermediate Of Cytochrome C Oxidase Protein Of 15 KDa;Cytochrome C Oxidase Assembly Protein 1 Homolog;Chromosome 7 Open Reading Frame 44
  Molecule Type
Protein coding
  Position On Chromosome
chr7(Start:43608452 - End:43729717)
  Strand
-
  Uniprot Entry
Q9GZY4 
  ENSG ID
ENSG00000106603 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce C7orf44 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 c-Abl kinase regulates neutrophil extracellular trap formation, inflammation, and tissue damage in severe acute pancreatitis. J Leukoc Biol. 2019 Aug;106(2):455-466. doi: 10.1002/JLB.3A0618-222RR. Epub 2019 Mar 12.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.