Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11940)
  Official Symbol
CMSS1
  Official Full Name
Cms1 Ribosomal Small Subunit Homolog
  Synonym
Cms1 Ribosomal Small Subunit Homolog;C3orf26;Protein CMSS1;MGC4308;Cms1 Ribosomal Small Subunit Homolog (Yeast);Chromosome 3 Open Reading Frame 26
  Molecule Type
Protein coding
  Position On Chromosome
chr3(Start:99817837 - End:100181732)
  Strand
+
  Uniprot Entry
Q9BQ75 
  ENSG ID
ENSG00000184220 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Arachidonic acid could induce C3orf26 gene hypermethylation in THP-1 cells.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [1]
     Description
Valerate has been shown to hypermethylate C3orf26 CpG site in breast cancer cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.

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