Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11921)
  Official Symbol
ADPRM
  Official Full Name
ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent
  Synonym
ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent;C17orf48;MDS006;Manganese-Dependent ADP-Ribose/CDP-Alcohol Diphosphatase;EC 3.6.1.13
  Molecule Type
Protein coding
  Position On Chromosome
chr17(Start:10697594 - End:10711558)
  Strand
+
  Uniprot Entry
Q3LIE5 
  ENSG ID
ENSG00000170222 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce C17orf48 gene hypermethylation in THP-1 cells.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Valerate has been shown to hypermethylate C17orf48 CpG site in breast cancer cells.

References
1 Epigenetics: A New Bridge between Nutrition and Health. Adv Nutr. 2010 Nov;1(1):8-16. doi: 10.3945/an.110.1004. Epub 2010 Nov 16.
2 Synergistic Effect in Core Microbiota Associated with Sulfur Metabolism in Spontaneous Chinese Liquor Fermentation Appl Environ Microbiol. 2017 Dec 1;83(24):e01475-17. doi: 10.1128/AEM.01475-17. Print 2017 Dec 15.
3 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
4 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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