Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11919)
  Official Symbol
RUSF1
  Official Full Name
RUS Family Member 1
  Synonym
C16orf58;RUS Family Member 1;RUS1 Homolog;Root UVB Sensitivity;Chromosome 16 Open Reading Frame 58;UPF0420 Protein C16orf58;FLJ13868
  Molecule Type
Protein coding
  Position On Chromosome
chr16(Start:31489471 - End:31509309)
  Strand
-
  Uniprot Entry
Q96GQ5 
  ENSG ID
ENSG00000140688 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce C16orf58 gene hypermethylation in THP-1 cells.

References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Antimicrobial production by strictly anaerobic Clostridium spp Int J Antimicrob Agents. 2020 May;55(5):105910. doi: 10.1016/j.ijantimicag.2020.105910. Epub 2020 Jan 25.

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