Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11909)
  Official Symbol
PROSER2
  Official Full Name
Proline And Serine Rich 2
  Synonym
Proline And Serine Rich 2;Proline And Serine-Rich Protein 2;C10orf47;MGC35403;Chromosome 10 Open Reading Frame 47
  Molecule Type
Protein coding
  Position On Chromosome
chr10(Start:11823339 - End:11872277)
  Strand
+
  Uniprot Entry
Q86WR7 
  ENSG ID
ENSG00000148426 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         QA46: Outcome of delivery Fetal intolerance of labor [Outcome of delivery]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce C10orf47 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. Clin Cancer Res. 2004 Feb 1;10(3):1150-9. doi: 10.1158/1078-0432.ccr-0747-3.

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