Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11896)
  Official Symbol
BCAT2
  Official Full Name
Branched Chain Amino Acid Transaminase 2
  Synonym
Branched Chain Amino Acid Transaminase 2;BCAM;BCT2;Branched-Chain-Amino-Acid Aminotransferase, Mitochondrial;Branched Chain Aminotransferase 2, Mitochondrial;Placental Protein 18;EC 2.6.1.42;Branched Chain Amino-Acid Transaminase 2, Mitochondrial;ECA40
  Molecule Type
Protein coding
  Position On Chromosome
chr19(Start:48795062 - End:48811029)
  Strand
-
  Uniprot Entry
O15382 
  ENSG ID
ENSG00000105552 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         FB83: Low bone mass disorders Primary osteoporosis [Low bone mass disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce BCAT2 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. Clin Cancer Res. 2004 Feb 1;10(3):1150-9. doi: 10.1158/1078-0432.ccr-0747-3.

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