Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11879)
  Official Symbol
ASB7
  Official Full Name
Ankyrin Repeat And SOCS Box Containing 7
  Synonym
Ankyrin Repeat And SOCS Box Containing 7;Ankyrin Repeat And SOCS Box Protein 7;Ankyrin Repeat And SOCS Box-Containing 7;ASB-7
  Molecule Type
Protein coding
  Position On Chromosome
chr15(Start:100602589 - End:100651701)
  Strand
+
  Uniprot Entry
Q9H672 
  ENSG ID
ENSG00000183475 
    Disease Relevance (Click to Show/Hide)
         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: S-Adenosyl Methionine (SAM)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
S-Adenosylmethionine was proved to be increase ASB7 methylation in HT-29 cells.(P value = 0.045)

References
1 S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression. Cells. 2020 Aug 9;9(8):1864. doi: 10.3390/cells9081864.
2 Progress in the microbial production of S-adenosyl-L-methionine World J Microbiol Biotechnol. 2016 Sep;32(9):153. doi: 10.1007/s11274-016-2102-8. Epub 2016 Jul 27.

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