Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11875)
  Official Symbol
ARL2
  Official Full Name
ADP Ribosylation Factor Like GTPase 2
  Synonym
ADP Ribosylation Factor Like GTPase 2;ARFL2;ADP-Ribosylation Factor-Like Protein;ADP-Ribosylation Factor-Like 2;MRCS1
  Molecule Type
Protein coding
  Position On Chromosome
chr11(Start:65014160 - End:65022184)
  Strand
+
  Uniprot Entry
P36404 
  ENSG ID
ENSG00000213465 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce ARL2 gene hypermethylation in THP-1 cells.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 c-Abl kinase regulates neutrophil extracellular trap formation, inflammation, and tissue damage in severe acute pancreatitis. J Leukoc Biol. 2019 Aug;106(2):455-466. doi: 10.1002/JLB.3A0618-222RR. Epub 2019 Mar 12.

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